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Losartan Carboxylic Acid
CAS No. 124750-92-1
Losartan Carboxylic Acid ( EXP-3174; EXP 3174;Losartan Carboxylic Acid )
Catalog No. M17904 CAS No. 124750-92-1
EXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 132 | In Stock |
|
| 50MG | 237 | In Stock |
|
| 100MG | 354 | In Stock |
|
| 200MG | 518 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLosartan Carboxylic Acid
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NoteResearch use only, not for human use.
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Brief DescriptionEXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation.
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DescriptionEXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
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SynonymsEXP-3174; EXP 3174;Losartan Carboxylic Acid
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PathwayOthers
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TargetOther Targets
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RecptorAT1 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number124750-92-1
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Formula Weight436.9
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Molecular FormulaC22H21ClN6O2
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Purity98%
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Solubility——
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SMILESc1(n(c(c(n1)Cl)C(=O)O)Cc1ccc(cc1)c1c(cccc1)c1n[nH]nn1)CCCC
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Chemical Name1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Choi JS, Choi JS, Choi DH. Effects of licochalcon A on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats. Pharmazie. 2013 Nov;68(11):882-8.
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